Advancing HIV Broadly Neutralizing Antibodies : From Discovery to the Clinic
Regardless of substantial progress in confronting the worldwide HIV-1 epidemic since its inception within the 1980s, higher approaches for each therapy and prevention will probably be mandatory to finish the epidemic and stay a high public well being precedence. Antiretroviral remedy (ART) has been efficient in extending lives, however at a price of lifelong adherence to therapy. Broadly neutralizing antibodies (bNAbs) are directed to conserved areas of the HIV-1 envelope glycoprotein trimer (Env) and might block an infection if current on the time of viral publicity. The therapeutic utility of bNAbs holds nice promise, and progress is being made towards their improvement for widespread medical use. In comparison with the present normal of care of small molecule-based ART, bNAbs provide: (1) lowered toxicity; (2) the benefits of prolonged half-lives that will bypass day by day dosing necessities; and (3) the potential to include a wider immune response by way of Fc signaling. Current advances in discovery expertise can allow system-wide mining of the immunoglobulin repertoire and can proceed to speed up isolation of subsequent era potent bNAbs. Passive switch research in pre-clinical fashions and medical trials have demonstrated the utility of bNAbs in blocking or limiting transmission and reaching viral suppression.
These research have helped to outline the window of alternative for optimum intervention to attain viral clearance, both utilizing bNAbs alone or together with ART. None of those advances with bNAbs can be potential with out technological developments and increasing the cohorts of donor participation. Collectively these components fueled the exceptional development in bNAb improvement. Right here, we assessment the event of bNAbs as therapies for HIV-1, exploring advances in discovery, insights from animal fashions and early medical trials, and improvements to optimize their medical potential by way of efforts to increase half-life, maximize the contribution of Fc effector features, preclude escape by way of multiepitope concentrating on, and the potential for sustained supply.
Signs, antibody ranges and vaccination perspective after asymptomatic to average COVID-19 an infection in 200 healthcare employees
Goal: In Germany, the willingness to be vaccinated in opposition to COVID-19 is somewhat low amongst medical workers. We collected knowledge on signs, antibody titers and vaccination readiness from clinic staff at a municipal clinic who had already been by way of a COVID-19 an infection (asymptomatic to average). We additionally examined the antibody titers for his or her potential significance as a person decision-making help with regard to vaccination.
Methodology: 200 staff of our municipal clinics have been included within the examine. COVID-19 antibody dedication was carried out utilizing an ELISA (EUROIMMUN™, PerkinElmer, Inc. Firm) . The contributors got an nameless questionnaire containing anthropometrical points, signs of the an infection and questions in regards to the vaccination resolution. Lastly, the antibody ranges have been reported to the contributors and the perspective in the direction of a vaccination was reevaluated.
Outcomes: In all 200 contributors who had already gone by way of a COVID-19 an infection, 75 staff have been in favor of a vaccination (37.5%), 96 have been against vaccination (48%), and 29 have been undecided (14.5%). Within the totally different occupational teams, the constructive development when it comes to willingness to be vaccinated was highest amongst physicians and is least amongst nurses . The antibody outcomes confirmed appreciable variation in titer ranges and subsequently didn’t correlate with illness severity in asymptomatic to reasonably ailing individuals. We additionally noticed a pro-vaccination development with growing age of the contributors. The specifically-asked symptom of cutaneous hyperesthesia throughout COVID-19 an infection occurred in 5% of the contributors.
Conclusion: In medical personnel who had already suffered from a COVID-19 an infection, the willingness to obtain a vaccination tends to be highest amongst physicians, and lowest in nurses , and will increase with age. For the overwhelming majority of these affected, data of the antibody titers solely reinforces the vaccination resolution made beforehand and thus doesn’t contribute to a change in vaccination resolution. The specifically-requested symptom of cutaneous hyperesthesia throughout COVID-19 an infection was unexpectedly frequent.
labonet
Recombinant Bothrops insularis Snake venom serine protease BITS01A
MBS1389341-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1115
Recombinant Bothrops insularis Snake venom serine protease BITS01A
MBS1389341-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 740
Recombinant Bothrops insularis Snake venom serine protease BITS01A
MBS1389341-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 905
Recombinant Bothrops insularis Snake venom serine protease BITS01A
MBS1389341-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 890
Recombinant Bothrops insularis Snake venom serine protease BITS01A
MBS1389341-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1060
Recombinant Bothrops insularis Snake venom vascular endothelial growth factor toxin
MBS1325913-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops insularis Snake venom vascular endothelial growth factor toxin
MBS1325913-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops insularis Snake venom vascular endothelial growth factor toxin
MBS1325913-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops insularis Snake venom vascular endothelial growth factor toxin
MBS1325913-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops insularis Snake venom vascular endothelial growth factor toxin
MBS1325913-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops insularis Calglandulin
MBS1428188-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1075
Recombinant Bothrops insularis Calglandulin
MBS1428188-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 665
Recombinant Bothrops insularis Calglandulin
MBS1428188-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 830
Recombinant Bothrops insularis Calglandulin
MBS1428188-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 775
Recombinant Bothrops insularis Calglandulin
MBS1428188-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 970
Recombinant Bothrops insularis Phospholipase A2 2
MBS1233506-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1030
Recombinant Bothrops insularis Phospholipase A2 2
MBS1233506-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 605
Recombinant Bothrops insularis Phospholipase A2 2
MBS1233506-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 785
Recombinant Bothrops insularis Phospholipase A2 2
MBS1233506-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 700
Recombinant Bothrops insularis Phospholipase A2 2
MBS1233506-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 915
Recombinant Bothrops insularis Bothroinsularin subunit alpha
MBS1189134-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1055
Recombinant Bothrops insularis Bothroinsularin subunit alpha
MBS1189134-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 635
Recombinant Bothrops insularis Bothroinsularin subunit alpha
MBS1189134-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 805
Recombinant Bothrops insularis Bothroinsularin subunit alpha
MBS1189134-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 740
Recombinant Bothrops insularis Bothroinsularin subunit alpha
MBS1189134-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 945
Recombinant Bothrops insularis Bothroinsularin subunit beta
MBS1124819-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1050
Recombinant Bothrops insularis Bothroinsularin subunit beta
MBS1124819-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 630
Recombinant Bothrops insularis Bothroinsularin subunit beta
MBS1124819-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops insularis Bothroinsularin subunit beta
MBS1124819-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 730
Recombinant Bothrops insularis Bothroinsularin subunit beta
MBS1124819-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 940
Recombinant Bothrops insularis C-type lectin BiL
MBS1374301-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1055
Recombinant Bothrops insularis C-type lectin BiL
MBS1374301-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 640
Recombinant Bothrops insularis C-type lectin BiL
MBS1374301-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 810
Recombinant Bothrops insularis C-type lectin BiL
MBS1374301-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 745
Recombinant Bothrops insularis C-type lectin BiL
MBS1374301-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 950
Recombinant Bothrops insularis Phospholipase A2 BITP01A
MBS1336656-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops insularis Phospholipase A2 BITP01A
MBS1336656-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops insularis Phospholipase A2 BITP01A
MBS1336656-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops insularis Phospholipase A2 BITP01A
MBS1336656-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops insularis Phospholipase A2 BITP01A
MBS1336656-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops insularis L-amino-acid oxidase
MBS1215911-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 975
Recombinant Bothrops insularis L-amino-acid oxidase
MBS1215911-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 535
Recombinant Bothrops insularis L-amino-acid oxidase
MBS1215911-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 725
Recombinant Bothrops insularis L-amino-acid oxidase
MBS1215911-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 635
Recombinant Bothrops insularis L-amino-acid oxidase
MBS1215911-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 850
Recombinant Bothrops insularis Zinc metalloproteinase BITM02A
MBS1379001-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1120
Recombinant Bothrops insularis Zinc metalloproteinase BITM02A
MBS1379001-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 700
Recombinant Bothrops insularis Zinc metalloproteinase BITM02A
MBS1379001-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 875
Recombinant Bothrops insularis Zinc metalloproteinase BITM02A
MBS1379001-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 840
Recombinant Bothrops insularis Zinc metalloproteinase BITM02A
MBS1379001-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1020
Recombinant Bothrops insularis Zinc metalloproteinase/disintegrin
MBS1296824-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1120
Recombinant Bothrops insularis Zinc metalloproteinase/disintegrin
MBS1296824-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 700
Recombinant Bothrops insularis Zinc metalloproteinase/disintegrin
MBS1296824-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 875
Recombinant Bothrops insularis Zinc metalloproteinase/disintegrin
MBS1296824-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 840
Recombinant Bothrops insularis Zinc metalloproteinase/disintegrin
MBS1296824-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1020
Recombinant Bothrops insularis Zinc metalloproteinase-disintegrin BITM06A
MBS1359286-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1290
Recombinant Bothrops insularis Zinc metalloproteinase-disintegrin BITM06A
MBS1359286-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 970
Recombinant Bothrops insularis Zinc metalloproteinase-disintegrin BITM06A
MBS1359286-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 1085
Recombinant Bothrops insularis Zinc metalloproteinase-disintegrin BITM06A
MBS1359286-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 1135
Recombinant Bothrops insularis Zinc metalloproteinase-disintegrin BITM06A
MBS1359286-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1235
Native Bothrops atrox snake Defibrase, 100BU/mg
PHAM-176
Creative Enzymes
50 ug
EUR 298
Description: 100BU/mg
Recombinant Bothrops asper Snake venom metalloproteinase BaP1
CSB-EP306655BUT
Cusabio
9374 mg
Ask for price
Recombinant Bothrops jararaca Snake venom serine protease BPA
MBS1468343-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1120
Recombinant Bothrops jararaca Snake venom serine protease BPA
MBS1468343-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 745
Recombinant Bothrops jararaca Snake venom serine protease BPA
MBS1468343-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 905
Recombinant Bothrops jararaca Snake venom serine protease BPA
MBS1468343-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 890
Recombinant Bothrops jararaca Snake venom serine protease BPA
MBS1468343-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1060
Recombinant Bothrops jararaca Snake venom serine protease HS112
MBS1374706-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1125
Recombinant Bothrops jararaca Snake venom serine protease HS112
MBS1374706-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 740
Recombinant Bothrops jararaca Snake venom serine protease HS112
MBS1374706-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 905
Recombinant Bothrops jararaca Snake venom serine protease HS112
MBS1374706-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 885
Recombinant Bothrops jararaca Snake venom serine protease HS112
MBS1374706-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1055
Recombinant Bothrops jararaca Snake venom serine protease HS114
MBS1337157-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1120
Recombinant Bothrops jararaca Snake venom serine protease HS114
MBS1337157-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 745
Recombinant Bothrops jararaca Snake venom serine protease HS114
MBS1337157-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 905
Recombinant Bothrops jararaca Snake venom serine protease HS114
MBS1337157-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 890
Recombinant Bothrops jararaca Snake venom serine protease HS114
MBS1337157-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1060
Recombinant Bothrops alternatus Snake venom serine protease BthaTL
MBS1407936-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1115
Recombinant Bothrops alternatus Snake venom serine protease BthaTL
MBS1407936-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 740
Recombinant Bothrops alternatus Snake venom serine protease BthaTL
MBS1407936-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 905
Recombinant Bothrops alternatus Snake venom serine protease BthaTL
MBS1407936-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 890
Recombinant Bothrops alternatus Snake venom serine protease BthaTL
MBS1407936-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1060
Recombinant Bothrops jararacussu Snake venom serine protease homolog
MBS1355577-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1120
Recombinant Bothrops jararacussu Snake venom serine protease homolog
MBS1355577-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 745
Recombinant Bothrops jararacussu Snake venom serine protease homolog
MBS1355577-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 910
Recombinant Bothrops jararacussu Snake venom serine protease homolog
MBS1355577-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 895
Recombinant Bothrops jararacussu Snake venom serine protease homolog
MBS1355577-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1065
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
CSB-EP308157BIY
Cusabio
2671 mg
Ask for price
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
MBS1242089-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 375
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
MBS1242089-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 635
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
MBS1242089-1mgEColi
MyBiosource
1mg(E-Coli)
EUR 1925
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
MBS1242089-5x1mgEColi
MyBiosource
5x1mg(E-Coli)
EUR 8405
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
RPC27582-100ug
Biomatik Corporation
100ug
EUR 801.9
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
RPC27582-1mg
Biomatik Corporation
1mg
EUR 2885.2
Recombinant Bothrops leucurus Snake venom metalloproteinase leucurolysin-A
RPC27582-20ug
Biomatik Corporation
20ug
EUR 448.1
Recombinant Bothrops jararaca Snake venom vascular endothelial growth factor toxin
MBS1279297-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops jararaca Snake venom vascular endothelial growth factor toxin
MBS1279297-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops jararaca Snake venom vascular endothelial growth factor toxin
MBS1279297-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops jararaca Snake venom vascular endothelial growth factor toxin
MBS1279297-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops jararaca Snake venom vascular endothelial growth factor toxin
MBS1279297-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops erythromelas Snake venom vascular endothelial growth factor toxin
MBS1364798-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops erythromelas Snake venom vascular endothelial growth factor toxin
MBS1364798-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops erythromelas Snake venom vascular endothelial growth factor toxin
MBS1364798-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops erythromelas Snake venom vascular endothelial growth factor toxin
MBS1364798-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops erythromelas Snake venom vascular endothelial growth factor toxin
MBS1364798-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Drosophila insularis Alcohol dehydrogenase (Adh)
MBS1310241-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1135
Recombinant Drosophila insularis Alcohol dehydrogenase (Adh)
MBS1310241-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 770
Recombinant Drosophila insularis Alcohol dehydrogenase (Adh)
MBS1310241-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 925
Recombinant Drosophila insularis Alcohol dehydrogenase (Adh)
MBS1310241-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 920
Recombinant Drosophila insularis Alcohol dehydrogenase (Adh)
MBS1310241-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1085
Recombinant Drosophila insularis Period circadian protein (per)
MBS1069345-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1265
Recombinant Drosophila insularis Period circadian protein (per)
MBS1069345-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 935
Recombinant Drosophila insularis Period circadian protein (per)
MBS1069345-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 1055
Recombinant Drosophila insularis Period circadian protein (per)
MBS1069345-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 1125
Recombinant Drosophila insularis Period circadian protein (per)
MBS1069345-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 1200
Recombinant Mogera insularis Cytochrome b (MT-CYB), partial
MBS7099873-INQUIRE
MyBiosource
INQUIRE
Ask for price
Recombinant Dipodomys insularis Cytochrome b (MT-CYB), partial
MBS7083547-INQUIRE
MyBiosource
INQUIRE
Ask for price
Recombinant Bothrops jararacussu Phospholipase A2 bothropstoxin-2
MBS1054417-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops jararacussu Phospholipase A2 bothropstoxin-2
MBS1054417-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops jararacussu Phospholipase A2 bothropstoxin-2
MBS1054417-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops jararacussu Phospholipase A2 bothropstoxin-2
MBS1054417-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops jararacussu Phospholipase A2 bothropstoxin-2
MBS1054417-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops asper Snaclec aspercetin subunit beta
MBS1207511-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 985
Recombinant Bothrops asper Snaclec aspercetin subunit beta
MBS1207511-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 550
Recombinant Bothrops asper Snaclec aspercetin subunit beta
MBS1207511-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 740
Recombinant Bothrops asper Snaclec aspercetin subunit beta
MBS1207511-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 655
Recombinant Bothrops asper Snaclec aspercetin subunit beta
MBS1207511-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 865
Recombinant Bothrops jararaca Snaclec botrocetin subunit beta
MBS1262342-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops jararaca Snaclec botrocetin subunit beta
MBS1262342-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops jararaca Snaclec botrocetin subunit beta
MBS1262342-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops jararaca Snaclec botrocetin subunit beta
MBS1262342-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 730
Recombinant Bothrops jararaca Snaclec botrocetin subunit beta
MBS1262342-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops asper Snaclec aspercetin subunit alpha
MBS1041979-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 985
Recombinant Bothrops asper Snaclec aspercetin subunit alpha
MBS1041979-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 550
Recombinant Bothrops asper Snaclec aspercetin subunit alpha
MBS1041979-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 740
Recombinant Bothrops asper Snaclec aspercetin subunit alpha
MBS1041979-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 655
Recombinant Bothrops asper Snaclec aspercetin subunit alpha
MBS1041979-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 865
Recombinant Bothrops jararaca Snaclec botrocetin subunit alpha
MBS1089614-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1055
Recombinant Bothrops jararaca Snaclec botrocetin subunit alpha
MBS1089614-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 635
Recombinant Bothrops jararaca Snaclec botrocetin subunit alpha
MBS1089614-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 810
Recombinant Bothrops jararaca Snaclec botrocetin subunit alpha
MBS1089614-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 740
Recombinant Bothrops jararaca Snaclec botrocetin subunit alpha
MBS1089614-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 945
Recombinant Bothrops jararacussu Phospholipase A2 homolog bothropstoxin-1
MBS1398251-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops jararacussu Phospholipase A2 homolog bothropstoxin-1
MBS1398251-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 620
Recombinant Bothrops jararacussu Phospholipase A2 homolog bothropstoxin-1
MBS1398251-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 795
Recombinant Bothrops jararacussu Phospholipase A2 homolog bothropstoxin-1
MBS1398251-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops jararacussu Phospholipase A2 homolog bothropstoxin-1
MBS1398251-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops jararaca Bothrojaracin subunit beta
MBS1429426-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1050
Recombinant Bothrops jararaca Bothrojaracin subunit beta
MBS1429426-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 630
Recombinant Bothrops jararaca Bothrojaracin subunit beta
MBS1429426-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops jararaca Bothrojaracin subunit beta
MBS1429426-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 730
Recombinant Bothrops jararaca Bothrojaracin subunit beta
MBS1429426-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 940
Recombinant Bothrops asper Phospholipase A2
MBS1098156-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops asper Phospholipase A2
MBS1098156-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops asper Phospholipase A2
MBS1098156-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops asper Phospholipase A2
MBS1098156-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops asper Phospholipase A2
MBS1098156-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops jararaca Bothrojaracin subunit alpha
MBS1330365-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1055
Recombinant Bothrops jararaca Bothrojaracin subunit alpha
MBS1330365-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 635
Recombinant Bothrops jararaca Bothrojaracin subunit alpha
MBS1330365-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 805
Recombinant Bothrops jararaca Bothrojaracin subunit alpha
MBS1330365-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 740
Recombinant Bothrops jararaca Bothrojaracin subunit alpha
MBS1330365-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 945
Recombinant Bothrops pictus Phospholipase A2
MBS1475966-005mgBaculovirus
MyBiosource
0.05mg(Baculovirus)
EUR 970
Recombinant Bothrops pictus Phospholipase A2
MBS1475966-005mgEColi
MyBiosource
0.05mg(E-Coli)
EUR 625
Recombinant Bothrops pictus Phospholipase A2
MBS1475966-005mgYeast
MyBiosource
0.05mg(Yeast)
EUR 800
Recombinant Bothrops pictus Phospholipase A2
MBS1475966-02mgEColi
MyBiosource
0.2mg(E-Coli)
EUR 805
Recombinant Bothrops pictus Phospholipase A2
MBS1475966-05mgEColi
MyBiosource
0.5mg(E-Coli)
EUR 880
Recombinant Bothrops leucurus Phospholipase A2
MBS1173421-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops leucurus Phospholipase A2
MBS1173421-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops leucurus Phospholipase A2
MBS1173421-002mgMammalianCell
MyBiosource
0.02mg(Mammalian-Cell)
EUR 1280
Recombinant Bothrops leucurus Phospholipase A2
MBS1173421-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops leucurus Phospholipase A2
MBS1173421-1mgEColi
MyBiosource
1mg(E-Coli)
EUR 1280
Recombinant Bothrops jararaca Phospholipase A2
MBS1258765-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 1045
Recombinant Bothrops jararaca Phospholipase A2
MBS1258765-002mgEColi
MyBiosource
0.02mg(E-Coli)
EUR 625
Recombinant Bothrops jararaca Phospholipase A2
MBS1258765-002mgYeast
MyBiosource
0.02mg(Yeast)
EUR 800
Recombinant Bothrops jararaca Phospholipase A2
MBS1258765-01mgEColi
MyBiosource
0.1mg(E-Coli)
EUR 725
Recombinant Bothrops jararaca Phospholipase A2
MBS1258765-01mgYeast
MyBiosource
0.1mg(Yeast)
EUR 935
Recombinant Bothrops jararaca Phospholipase A2
MBS7100979-005mgBaculovirus
MyBiosource
0.05mg(Baculovirus)
EUR 875
Recombinant Bothrops jararaca Phospholipase A2
MBS7100979-005mgEColi
MyBiosource
0.05mg(E-Coli)
EUR 495
Recombinant Bothrops jararaca Phospholipase A2
MBS7100979-005mgYeast
MyBiosource
0.05mg(Yeast)
EUR 695
Recombinant Bothrops jararaca Phospholipase A2
MBS7100979-02mgEColi
MyBiosource
0.2mg(E-Coli)
EUR 645
Recombinant Bothrops jararaca Phospholipase A2
MBS7100979-05mgEColi
MyBiosource
0.5mg(E-Coli)
EUR 705
Recombinant Bothrops jararaca Jararafibrase-3
MBS1119135-002mgBaculovirus
MyBiosource
0.02mg(Baculovirus)
EUR 970
Engineering a novel IgG-like bispecific antibody in opposition to enterovirus A71
Frequent outbreaks of enterovirus A71 (EVA71) happen within the Asia-Pacific space, and these are carefully related to extreme neurological signs in younger kids. No efficient antiviral remedy is at present obtainable for the therapy of EVA71 an infection. The event of monoclonal antibodies (mAbs) has demonstrated promise as a novel remedy for the prevention and therapy of infectious ailments. A number of medical situations have been handled utilizing bispecific or multi-specific antibodies that acknowledge two or extra distinct epitopes concurrently. Nevertheless, bispecific or multi-specific antibodies typically encounter protein expression and product stability issues.
On this examine, we developed an IgG-like bispecific antibody (E18-F1) comprising two anti-EVA71 antibodies: E18 mAb and llama-derived F1 single-domain antibody. E18-F1 was demonstrated to exhibit superior binding affinity and antiviral exercise in contrast with E18 or F1. Moreover , E18-F1 not solely improved survival charge, but in addition lowered medical indicators in human SCARB2 receptor (hSCARB2) transgenic mice challenged with a deadly dose of EVA71. Altogether, our outcomes reveal that E18-F1 is an easy format bispecific antibody with promising antiviral exercise for EVA71.