NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and thru transendocytosis into ligand cells

 

Aberrant NOTCH3 signaling and overexpression is oncogenic, related with most cancers stem cells and drug resistance, but therapeutic focusing on stays elusive. Right here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor by way of a protease cleavable linker to 2 antibodies with differential talents to inhibit signaling. The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization by way of each caveolin and clathrin-mediated pathways.

The non-inhibitory antibody additionally effectively endocytoses through clathrin with out inducing receptor clustering however with slower lysosomal co-localization kinetics. As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell loss of life in each cell sorts representing an atypical mechanism of ADC cytotoxicity. Therapy of xenografts with NOTCH3-ADCs results in sustained tumor regressions, outperforms standard-of-care chemotherapy, and permits focusing on of tumors that overexpress NOTCH3 impartial of signaling inhibition.

Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses

Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising method to set off anti-tumor immune responses. Nonetheless, present molecular designs solely allow the usage of a small fraction of endogenous antibodies, limiting the therapeutic potential. Right here, we report Fc-binding antibody-recruiting molecules (Fc-ARMs) as the primary instance addressing this challenge. Fc-ARMs are composed of an Fc-binding peptide and a focusing on ligand, enabling the exploitation of endogenous antibodies by way of fixed affinity to the Fc area of antibodies, whose sequence is conserved in distinction to the Fab area.

We present that Fc-ARM focusing on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α⁺ most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro. Fc-ARMs efficiently interacted with antibodies in vivo and collected in tumors. Moreover, Fc-ARMs recruited antibodies to suppress tumor development in a mouse mannequin. Thus, Fc-ARMs have the potential to be a novel class of most cancers immunotherapeutic brokers.

Active Recombinant Human TGFR-2 Protein
RP00239	Abclonal	10 μg	EUR 35.75

Rat TGFR ELISA Kit
ERT0062	Abclonal	96Tests	EUR 625.2

Goat TGFR ELISA Kit
EGTT0062	Abclonal	96Tests	EUR 625.2

Sheep TGFR ELISA Kit
EST0062	Abclonal	96Tests	EUR 625.2

Mouse TGFR ELISA Kit
EMT0062	Abclonal	96Tests	EUR 625.2

Bovine TGFR ELISA Kit
EBT0062	Abclonal	96Tests	EUR 625.2

Canine TGFR ELISA Kit
ECT0062	Abclonal	96Tests	EUR 625.2

Rabbit TGFR ELISA Kit
ERTT0062	Abclonal	96Tests	EUR 625.2

Monkey TGFR ELISA Kit
EMKT0062	Abclonal	96Tests	EUR 625.2

Chicken TGFR ELISA Kit
ECKT0062	Abclonal	96Tests	EUR 625.2

Porcine TGFR ELISA Kit
EPT0062	Abclonal	96Tests	EUR 625.2

Anserini TGFR ELISA Kit
EAT0062	Abclonal	96Tests	EUR 625.2

Human ALK-1 Antibody Pair Set
ABPR-ZB169	Creative Diagnostics	5 plates, 15 plates	Ask for price
Description: Quantitative determination of Human ALK-1

Guinea Pig TGFR ELISA Kit
EGT0062	Abclonal	96Tests	EUR 625.2

Recombinant Human ALK-1 Protein
VAng-2860Lsx-10g	Creative Biolabs	10 µg	EUR 736.8
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein
VAng-2860Lsx-1mg	Creative Biolabs	1 mg	EUR 16605.6
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein
MBS9141695-0005mg	MyBiosource	0.005mg	EUR 135

Recombinant Human ALK-1 Protein
MBS9141695-002mg	MyBiosource	0.02mg	EUR 165

Recombinant Human ALK-1 Protein
MBS9141695-005mg	MyBiosource	0.05mg	EUR 195

Recombinant Human ALK-1 Protein
MBS9141695-01mg	MyBiosource	0.1mg	EUR 250

Recombinant Human ALK-1 Protein
MBS9141695-5x01mg	MyBiosource	5x0.1mg	EUR 945

GOAT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML
9450431	Lampire Biologicals Laboratories	1ML	EUR 207.65

RABBIT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML
9450511	Lampire Biologicals Laboratories	1ML	EUR 228.15

Human ACVRL1 / ALK-1, Fc Tag
E24PHA006	EnoGene	50 μg	EUR 180

Human ACVRL1 / ALK-1, His Tag
E24PHA007	EnoGene	50 μg	EUR 225

Human ALK-1/ACVRL1 ELISA Kit
EK5715	SAB	96 tests	EUR 599

Human ALK-1/ACVRL1 ELISA Kit
MBS8123812-5x96Tests	MyBiosource	5x96Tests	EUR 2395

Human ALK-1/ACVRL1 ELISA Kit
MBS8123812-96Tests	MyBiosource	96Tests	EUR 520

Goat anti Human IgG (Alk Phos)
43C-CB0963	Fitzgerald	1 mg	EUR 351
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43C-CB0978	Fitzgerald	1 mg	EUR 394
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgM (Alk Phos)
43C-CB0999	Fitzgerald	1 mg	EUR 347
Description: Goat anti Human IgM secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-1169	Fitzgerald	1 mg	EUR 167
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-1175	Fitzgerald	1 mg	EUR 208
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-1192	Fitzgerald	1 mg	EUR 250
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-1204	Fitzgerald	500 ug	EUR 293
Description: Goat anti Human IgG secondary antibody  (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-IG012alk	Fitzgerald	1 ml	EUR 522
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
43R-IG165ALK	Fitzgerald	1 mg	EUR 208
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)
MBS538563-1mg	MyBiosource	1mg	EUR 620

Goat anti Human IgG (Alk Phos)
MBS538563-5x1mg	MyBiosource	5x1mg	EUR 2635

Goat anti Human IgG (Alk Phos)
MBS538573-1mg	MyBiosource	1mg	EUR 675

Goat anti Human IgG (Alk Phos)
MBS538573-5x1mg	MyBiosource	5x1mg	EUR 2890

Goat anti Human IgM (Alk Phos)
MBS538582-1mg	MyBiosource	1mg	EUR 620

Goat anti Human IgM (Alk Phos)
MBS538582-5x1mg	MyBiosource	5x1mg	EUR 2635

Goat anti Human IgG (Alk Phos)
MBS539168-1mL	MyBiosource	1mL	EUR 690

Goat anti Human IgG (Alk Phos)
MBS539168-5x1mL	MyBiosource	5x1mL	EUR 2960

Goat anti Human IgG (Alk Phos)
MBS539272-1mg	MyBiosource	1mg	EUR 395

Goat anti Human IgG (Alk Phos)
MBS539272-5x1mg	MyBiosource	5x1mg	EUR 1615

Human ALK-1 HEK293 Overexpression Lysate
MBS8113429-03mg	MyBiosource	0.3mg	EUR 280

Human ALK-1 HEK293 Overexpression Lysate
MBS8113429-5x03mg	MyBiosource	5x0.3mg	EUR 1205

Human ALK-1 HEK293 Overexpression Lysate
MBS8113430-03mg	MyBiosource	0.3mg	EUR 280

Human ALK-1 HEK293 Overexpression Lysate
MBS8113430-5x03mg	MyBiosource	5x0.3mg	EUR 1205

Rabbit anti Human IgG (Alk Phos)
43C-CB0949	Fitzgerald	1 mg	EUR 44
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)
43C-CB0956	Fitzgerald	1 mg	EUR 387
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)
43C-CB0970	Fitzgerald	1 mg	EUR 387
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgM (Alk Phos)
43C-CB9106	Fitzgerald	1 mg	EUR 425
Description: Rabbit anti Human IgM secondary antibody (Alk Phos)

Rabbit anti Human IgA (Alk Phos)
43C-CB9120	Fitzgerald	1 mg	EUR 385
Description: Rabbit anti Human IgA secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)
MBS538554-1mg	MyBiosource	1mg	EUR 790

Rabbit anti Human IgG (Alk Phos)
MBS538554-5x1mg	MyBiosource	5x1mg	EUR 3400

Rabbit anti Human IgG (Alk Phos)
MBS538559-1mg	MyBiosource	1mg	EUR 665

Rabbit anti Human IgG (Alk Phos)
MBS538559-5x1mg	MyBiosource	5x1mg	EUR 2850

Rabbit anti Human IgG (Alk Phos)
MBS538569-1mg	MyBiosource	1mg	EUR 665

Rabbit anti Human IgG (Alk Phos)
MBS538569-5x1mg	MyBiosource	5x1mg	EUR 2850

Rabbit anti Human IgM (Alk Phos)
MBS538796-1mg	MyBiosource	1mg	EUR 735

Rabbit anti Human IgM (Alk Phos)
MBS538796-5x1mg	MyBiosource	5x1mg	EUR 3160

Rabbit anti Human IgA (Alk Phos)
MBS538805-1mg	MyBiosource	1mg	EUR 665

Rabbit anti Human IgA (Alk Phos)
MBS538805-5x1mg	MyBiosource	5x1mg	EUR 2850

Mouse Anti Human ALK/P80 Protein
MBS140212-0005mg	MyBiosource	0.005mg	EUR 240

Mouse Anti Human ALK/P80 Protein
MBS140212-002mg	MyBiosource	0.02mg	EUR 310

Mouse Anti Human ALK/P80 Protein
MBS140212-01mg	MyBiosource	0.1mg	EUR 610

Mouse Anti Human ALK/P80 Protein
MBS140212-5x01mg	MyBiosource	5x0.1mg	EUR 2405

ALK-1 Matched ELISA Antibody Pair Set, Human
MBS8118180-15Plates	MyBiosource	15Plates	EUR 800

ALK-1 Matched ELISA Antibody Pair Set, Human
MBS8118180-5Plates	MyBiosource	5Plates	EUR 450

ALK-1 Matched ELISA Antibody Pair Set, Human
MBS8118180-5x15Plates	MyBiosource	5x15Plates	EUR 3695

ALK-1 Antibody
C10579-100ul	Assay Biotech	100μl	EUR 217
Description: ALK-1 Rabbit Polyclonal Antibody

ALK-1 Antibody
C10579-50ul	Assay Biotech	50μl	EUR 143.5
Description: ALK-1 Rabbit Polyclonal Antibody

ALK-1 Antibody
C30105-100ul	Assay Biotech	100μl	EUR 217
Description: ALK-1 Rabbit Polyclonal Antibody

ALK-1 Antibody
C30105-50ul	Assay Biotech	50μl	EUR 143.5
Description: ALK-1 Rabbit Polyclonal Antibody

ALK-1
MBS370004-01mLConcentrate	MyBiosource	0.1mL(Concentrate)	EUR 350

ALK-1
MBS370004-05mLConcentrate	MyBiosource	0.5mL(Concentrate)	EUR 695

ALK-1
MBS370004-15mLRTU	MyBiosource	15mL(RTU)	EUR 905

ALK-1
MBS370004-3mLRTU	MyBiosource	3mL(RTU)	EUR 325

ALK-1
MBS370004-7mLRTU	MyBiosource	7mL(RTU)	EUR 535

Nori® Human ALK-1 ELISA Kit
GR111542	Genorise Scientific	96-well	EUR 461

GOAT ANTI HUMAN IGA, U CHAIN, INTACT IGG, ALK PHOS, 1 ML
9450381	Lampire Biologicals Laboratories	1ML	EUR 258.89

GOAT ANTI HUMAN IGG, FCY FRAG, INTACT IGG, ALK PHOS, 1 ML
9450581	Lampire Biologicals Laboratories	1ML	EUR 258.89

Human ALK and LTK ligand 1 (ALKAL1)
1-CSB-EP757795HU	Cusabio	Ask for price Ask for price Ask for price Ask for price Ask for price Ask for price	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli

GOAT ANTI HUMAN IGM, FC5U FRAG, INTACT IGG, ALK PHOS, 1 ML
9450641	Lampire Biologicals Laboratories	1ML	EUR 269.14

Human ALK-1 / ACVRL1 Protein, His Tag
AL1-H5228	ACROBIOSYSTEMS	100ug	EUR 2140
Description: Human ALK-1, His Tag (AL1-H5228) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Gln 118 (Accession # P37023).

Human ALK-1/ACVRL1 PicoKine ELISA Kit
EK1518	BosterBio	96 wells	EUR 510
Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

OKRC00141-96W - ALK-1 ELISA Kit (Human)
OKRC00141-96W	Aviva Systems Biology	96Wells	EUR 550

Human ALK-1/ACVRL1 PicoKine ELISA Kit
MBS178556-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2755

Human ALK-1/ACVRL1 PicoKine ELISA Kit
MBS178556-96StripWells	MyBiosource	96-Strip-Wells	EUR 600

Recombinant Human ALK-1 protein (C-Fc)
CD02357-10ug	Jiaxing Korain Biotech Ltd (BT Labs)	10ug	EUR 71
Description: Recombinant Human Activin Receptor-Like Kinase 1 is produced by our Mammalian expression system and the target gene encoding Asp22-Gln118 is expressed with a Fc tag at the C-terminus.

Recombinant Human ALK-1 protein (C-Fc)
CD02357-50ug	Jiaxing Korain Biotech Ltd (BT Labs)	50ug	EUR 212
Description: Recombinant Human Activin Receptor-Like Kinase 1 is produced by our Mammalian expression system and the target gene encoding Asp22-Gln118 is expressed with a Fc tag at the C-terminus.

Goat anti Human IgG Fc (Alk Phos)
43-I24	Fitzgerald	100 ug	EUR 125
Description: Goat anti Human IgG Fc secondary antibody (Alk Phos)

GOAT ANTI HUMAN IgG (Fc):Alk. Phos.
MBS220035-1mg	MyBiosource	1mg	EUR 505

GOAT ANTI HUMAN IgG (Fc):Alk. Phos.
MBS220035-5x1mg	MyBiosource	5x1mg	EUR 2090

Goat anti Human IgG Fc (Alk Phos)
MBS539819-01mg	MyBiosource	0.1mg	EUR 235

Goat anti Human IgG Fc (Alk Phos)
MBS539819-5x01mg	MyBiosource	5x0.1mg	EUR 1005

Recombinant Human ALK-1 Protein, His Tag
E40KMP1394	EnoGene	20ug	EUR 495

ALK-1 Protein, Human, Recombinant (hFc Tag)
MBS8119980-01mg	MyBiosource	0.1mg	EUR 340

ALK-1 Protein, Human, Recombinant (hFc Tag)
MBS8119980-1mg	MyBiosource	1mg	EUR 1825

ALK-1 Protein, Human, Recombinant (hFc Tag)
MBS8119980-5x1mg	MyBiosource	5x1mg	EUR 8060

ALK-1 Protein, Human, Recombinant (His Tag)
MBS8119981-01mg	MyBiosource	0.1mg	EUR 340

ALK-1 Protein, Human, Recombinant (His Tag)
MBS8119981-1mg	MyBiosource	1mg	EUR 1825

ALK-1 Protein, Human, Recombinant (His Tag)
MBS8119981-5x1mg	MyBiosource	5x1mg	EUR 8060

Active Recombinant Human ALK-1/ACVRL1 Protein
RP00978	Abclonal	5 μg	EUR 39

Goat anti Human Kappa Chain (Alk Phos)
43C-CB9127	Fitzgerald	1 mg	EUR 403
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)
43R-1257	Fitzgerald	500 ug	EUR 398
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Kappa Chain (Alk Phos)
MBS536352-1mg	MyBiosource	1mg	EUR 745

Goat anti Human Kappa Chain (Alk Phos)
MBS536352-5x1mg	MyBiosource	5x1mg	EUR 3210

Goat anti Human Lambda Chain (Alk Phos)
43C-CB9134	Fitzgerald	1 mg	EUR 403
Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos)

Goat anti Human Lambda Chain (Alk Phos)
MBS536357-1mg	MyBiosource	1mg	EUR 745

Goat anti Human Lambda Chain (Alk Phos)
MBS536357-5x1mg	MyBiosource	5x1mg	EUR 3210

Rabbit Anti-Human ALK-1 monoclonal antibody, clone S215
CABT-ZB592	Creative Diagnostics	50 μl	EUR 520
Description: Rabbit

Rabbit Anti-Human ALK-1 monoclonal antibody, clone S135
CABT-ZB944	Creative Diagnostics	50 μl	EUR 520
Description: Rabbit

Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab)
E24CHA111	EnoGene	100 μg	EUR 225
Description: Available in various conjugation types.

Mouse anti Human ALK-6/BMPR1B Monoclonal Antibody
MBS2543390-006mL	MyBiosource	0.06mL	EUR 250

Mouse anti Human ALK-6/BMPR1B Monoclonal Antibody
MBS2543390-012mL	MyBiosource	0.12mL	EUR 370

Mouse anti Human ALK-6/BMPR1B Monoclonal Antibody
MBS2543390-02mL	MyBiosource	0.2mL	EUR 550

Goat anti Human IgG (H + L) (Alk Phos)
43C-CB0921	Fitzgerald	1 mg	EUR 152
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
43C-CB0928	Fitzgerald	1 mg	EUR 349
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
43C-CB0935	Fitzgerald	1 mg	EUR 464
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
43R-1145	Fitzgerald	1 mg	EUR 208
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
43R-1157	Fitzgerald	500 ug	EUR 208
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
43R-1163	Fitzgerald	500 ug	EUR 250
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)
MBS538538-1mg	MyBiosource	1mg	EUR 620

Goat anti Human IgG (H + L) (Alk Phos)
MBS538538-5x1mg	MyBiosource	5x1mg	EUR 2635

Goat anti Human IgG (H + L) (Alk Phos)
MBS538544-1mg	MyBiosource	1mg	EUR 800

Goat anti Human IgG (H + L) (Alk Phos)
MBS538544-5x1mg	MyBiosource	5x1mg	EUR 3445

Goat anti Human IgG (H + L) (Alk Phos)
MBS539848-1mg	MyBiosource	1mg	EUR 310

Goat anti Human IgG (H + L) (Alk Phos)
MBS539848-5x1mg	MyBiosource	5x1mg	EUR 1240

Human ALK And LTK Ligand 1 (ALKAL1) Protein
abx691053-100g	Abbexa	100 µg	EUR 962.5

Human ALK And LTK Ligand 1 (ALKAL1) Protein
abx691053-1mg	Abbexa	1 mg	Ask for price

Recombinant Human ALK-1 Protein (aa 22-503)
VAng-2854Lsx-100g	Creative Biolabs	100 µg	EUR 8440.8
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-503)
VAng-2854Lsx-50g	Creative Biolabs	50 µg	EUR 5454
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)
VAng-2856Lsx-1mg	Creative Biolabs	1 mg	EUR 3393.6
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)
VAng-2856Lsx-200g	Creative Biolabs	200 µg	EUR 2205.6
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)
VAng-2856Lsx-500g	Creative Biolabs	500 µg	EUR 2419.2
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

ALK sgRNA CRISPR Lentivector (Human) (Target 1)
K0074502	ABM	1.0 ug DNA	EUR 184.8

Anti-ALK-1 antibody
STJ96547	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to ALK-1.

Anti-ALK-1 antibody
STJ91563	St John's Laboratory	200 µl	EUR 236.4
Description: Rabbit polyclonal to ALK-1.

Rabbit anti Human IgG (H + L) (Alk Phos)
43C-CB0914	Fitzgerald	1 mg	EUR 391
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG + IgA + IgM (Alk Phos)
43R-1245	Fitzgerald	1 mg	EUR 152
Description: Goat anti Human IgG + IgA + IgM secondary antibody  (Alk Phos)

Goat anti Human IgG + IgA + IgM (Alk Phos)
43R-1251	Fitzgerald	500 ug	EUR 208
Description: Goat anti Human IgG + IgA + IgM secondary antibody  (Alk Phos)

Rabbit anti Human IgG (H + L) (Alk Phos)
43R-1269	Fitzgerald	1 mg	EUR 232
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Donkey anti Human IgG (H + L) (Alk Phos)
43R-ID001alk	Fitzgerald	500 ul	EUR 315
Description: Donkey anti Human IgG (H + L) secondary antibody (Alk Phos)

Rabbit anti Human IgG (H + L) (Alk Phos)
43-I23	Fitzgerald	1 mg	EUR 340
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Rabbit anti Human IgG (H + L) (Alk Phos)
MBS538531-1mg	MyBiosource	1mg	EUR 665

Rabbit anti Human IgG (H + L) (Alk Phos)
MBS538531-5x1mg	MyBiosource	5x1mg	EUR 2850

Donkey anti Human IgG (H + L) (Alk Phos)
MBS539122-05mL	MyBiosource	0.5mL	EUR 550

Donkey anti Human IgG (H + L) (Alk Phos)
MBS539122-5x05mL	MyBiosource	5x0.5mL	EUR 2320

Rabbit anti Human IgG (H + L) (Alk Phos)
MBS539847-1mg	MyBiosource	1mg	EUR 605

Rabbit anti Human IgG (H + L) (Alk Phos)
MBS539847-5x1mg	MyBiosource	5x1mg	EUR 2575

Goat anti Human IgM (mu chain) (Alk Phos)
43R-1227	Fitzgerald	1 mg	EUR 211
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)
43R-1233	Fitzgerald	500 ug	EUR 375
Description: Goat anti Human IgM (mu chain) secondary antibody  (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)
43R-1239	Fitzgerald	500 ug	EUR 375
Description: Goat anti Human IgM (mu chain) secondary antibody  (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)
43-I34	Fitzgerald	1 mg	EUR 176
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos)

Significance of hepatitis B floor antigen, IgM/IgG core antibody and hepatitis B virus DNA in blood donors

Introduction: Identification of hepatitis B virus carriers in blood donors is crucial as a way to keep away from transmission of the illness through blood transfusion.

Goal: To find out if blood donors with optimistic outcomes for serological markers HBsAg and anti-HBc have been hepatitis B virus DNA carriers.

Strategies: 12,745 samples have been collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. All samples that examined optimistic for one, two or all three markers have been analyzed with molecular strategies to find out the presence of viral DNA.

Outcomes: 27.5 % of the samples that have been reactive for anti-HBc alone and 100 % of these with optimistic outcomes for HbsAg and IgM/IgG anti-HBc have been recognized to include hepatitis B virus DNA (p = 0.001).

Conclusions: The collection of an infection markers, in addition to the detection strategies outline the outcomes. Performing two serological and one molecular take a look at is necessary as a way to establish hepatitis B virus carriers and forestall its transmission.

Introducción: La identificación de portadores del virus de la hepatitis B en donantes de sangre es imperativo para evitar la transmisión de la enfermedad a través de transfusiones sanguíneas.

Objetivo: Determinar si los donantes de sangre con resultados positivos en los marcadores serológicos HbsAg y anti-HBc eran portadores del ADN del virus de la hepatitis B.

Métodos: Se recolectaron 12 745 muestras de seis bancos de sangre ecuatorianos, las cuales fueron analizadas con pruebas serológicas para identificar marcadores infecciosos de HBsAg, anti-HBc, anti-HBs mediante ELISA automatizada. Todas las muestras positivas para uno, dos o los tres marcadores fueron analizadas con técnica molecular para determinar la presencia del ADN viral.

Resultados: Se identificó que 27.5 % de las muestras reactivas solo a anti-HBc y 100 % de las muestras con resultados positivos de HBsAg/anti-HBc-IgM/IgG presentaron ADN del virus de la hepatitis B (p = 0.001).

Conclusiones: La elección de los marcadores de infección y los métodos de detección definen los resultados. Es importante la realización de dos pruebas serológicas y una molecular para identificar a los portadores del virus de la hepatitis B y evitar su transmisión.

Two human antibodies to a meningococcal serogroup B vaccine antigen improve binding of complement Issue H by stabilizing the Issue H binding website

Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds a number of complement regulators, together with human Issue H (FH). FH binding protein (FHbp) is a element of two licensed meningococcal vaccines and in mice FHbp elicits antibodies that inhibit binding of FH to FHbp, which defeat the bacterial evasion mechanism. Nonetheless, people vaccinated with FHbp develop antibodies that improve binding of FH to the micro organism, which might restrict the effectiveness of the vaccines. Within the current examine, we present that two vaccine-elicited antibody fragments (Fabs) remoted from totally different human topics enhance binding of complement FH to meningococcal FHbp by ELISA.

The 2 Fabs have totally different results on the kinetics of FH binding to immobilized FHbp as measured by floor plasmon resonance. The 1.7- and a pair of.0-Å decision X-ray crystal constructions of the Fabs in complexes with FHbp illustrate that the 2 Fabs bind to related epitopes on the amino-terminal area of FHbp, adjoining to the FH binding website. Superposition fashions of ternary complexes of every Fab with FHbp and FH present that there’s possible minimal contact between the Fabs and FH. Collectively, the constructions reveal that the Fabs improve binding of FH to FHbp by altering the conformations and mobilities of two loops adjoining to the FH binding website of FHbp. As well as, the 1.5 Å-resolution construction of one of many remoted Fabs defines the structural rearrangements related to binding to FHbp. The FH-enhancing human Fabs, that are mirrored within the human polyclonal antibody responses, have necessary implications for tuning the effectiveness of FHbp-based vaccines.

 

Human Integrin alpha-5 ELISA Kit
MBS761812-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2045

Human Integrin alpha-5 ELISA Kit
MBS761812-96StripWells	MyBiosource	96-Strip-Wells	EUR 455

Human Integrin alpha-5 ELISA Kit
MBS2882218-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4630

Human Integrin alpha-5 ELISA Kit
MBS2882218-48StripWells	MyBiosource	48-Strip-Wells	EUR 440

Human Integrin alpha-5 ELISA Kit
MBS2882218-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2480

Human Integrin alpha-5 ELISA Kit
MBS2882218-96StripWells	MyBiosource	96-Strip-Wells	EUR 580

Human Integrin alpha-5 ELISA Kit
MBS9428739-5x96Tests	MyBiosource	5x96Tests	EUR 3385

Human Integrin alpha-5 ELISA Kit
MBS9428739-96Tests	MyBiosource	96Tests	EUR 735

Human Integrin Alpha 5 ELISA Kit
E01A5456	BlueGene	96T	EUR 700
Description: ELISA

Human Integrin Alpha 5 ELISA Kit
MBS094108-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Integrin Alpha 5 ELISA Kit
MBS094108-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Integrin Alpha 5 ELISA Kit
MBS094108-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Integrin Alpha 5 ELISA Kit
MBS094108-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human Integrin Alpha 5 ELISA Kit
IHUITGA5KT	Innovative research	each	EUR 700
Description: Human Integrin Alpha 5 ELISA Kit

Human Integrin Alpha 5 ELISA Kit
MBS7273513-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5685

Human Integrin Alpha 5 ELISA Kit
MBS7273513-48StripWells	MyBiosource	48-Strip-Wells	EUR 485

Human Integrin Alpha 5 ELISA Kit
MBS7273513-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3020

Human Integrin Alpha 5 ELISA Kit
MBS7273513-96StripWells	MyBiosource	96-Strip-Wells	EUR 690

Human Integrin Alpha 5 ELISA Kit
MBS3802124-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 6725

Human Integrin Alpha 5 ELISA Kit
MBS3802124-48StripWells	MyBiosource	48-Strip-Wells	EUR 550

Human Integrin Alpha 5 ELISA Kit
MBS3802124-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 3420

Human Integrin Alpha 5 ELISA Kit
MBS3802124-96StripWells	MyBiosource	96-Strip-Wells	EUR 765

Human Integrin Alpha 5 (ITGa5) Protein
20-abx067272	Abbexa	Ask for price Ask for price Ask for price Ask for price Ask for price	100 ug 10 ug 1 mg 200 ug 50 ug

Human Integrin Alpha 5 (ITGa5) Protein
abx067272-100g	Abbexa	100 µg	EUR 550

Human Integrin Alpha 5 (ITGa5) Protein
abx067272-10g	Abbexa	10 µg	EUR 212.5

Human Integrin Alpha 5 (ITGa5) Protein
abx067272-50g	Abbexa	50 µg	EUR 387.5

Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody
CABT-49626MH	Creative Diagnostics	0.1 mg	EUR 1650

Mouse anti Integrin alpha 5 (CD49e)
MBS570237-01mg	MyBiosource	0.1mg	EUR 515

Mouse anti Integrin alpha 5 (CD49e)
MBS570237-5x01mg	MyBiosource	5x0.1mg	EUR 2165

Human Integrin alpha-5(ITGA5) Elisa Kit
EK712764	AFG Bioscience LLC	96 Wells	EUR 0.29

Human Integrin alpha-5(ITGA5) Elisa kit
CSB-E17350h-24T	Cusabio	1 plate of 24 wells	EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5 (ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Integrin alpha-5(ITGA5) Elisa kit
1-CSB-E17350h	Cusabio	Ask for price Ask for price Ask for price	1 plate of 96 wells 10 plates of 96 wells each 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5(ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Integrin alpha-5(ITGA5) Elisa kit
YLA4349HU-48T	Shanghai YL Biotech	48T	Ask for price

Human Integrin alpha-5(ITGA5) Elisa kit
YLA4349HU-96T	Shanghai YL Biotech	96T	Ask for price

Human Integrin alpha-5,ITGA5 ELISA KIT
E3734Hu-1096T	Jiaxing Korain Biotech Ltd (BT Labs)	10*96T	EUR 4122

Human Integrin alpha-5,ITGA5 ELISA KIT
E3734Hu-48wells	Jiaxing Korain Biotech Ltd (BT Labs)	48 wells	EUR 300

Human Integrin alpha-5,ITGA5 ELISA KIT
E3734Hu-596T	Jiaxing Korain Biotech Ltd (BT Labs)	5*96T	EUR 2061

Human Integrin alpha-5,ITGA5 ELISA KIT
E3734Hu-96wells	Jiaxing Korain Biotech Ltd (BT Labs)	96 wells	EUR 458

Human Integrin alpha-5,ITGA5 ELISA KIT
E5482Hu-1096T	Jiaxing Korain Biotech Ltd (BT Labs)	10*96T	EUR 4122

Human Integrin alpha-5,ITGA5 ELISA KIT
E5482Hu-48wells	Jiaxing Korain Biotech Ltd (BT Labs)	48 wells	EUR 300

Human Integrin alpha-5,ITGA5 ELISA KIT
E5482Hu-596T	Jiaxing Korain Biotech Ltd (BT Labs)	5*96T	EUR 2061

Human Integrin alpha-5,ITGA5 ELISA KIT
E5482Hu-96wells	Jiaxing Korain Biotech Ltd (BT Labs)	96 wells	EUR 458

Human Integrin alpha-5 (ITGA5) ELISA Kit
RK11332	Abclonal	96T	EUR 280

Human Integrin alpha-5, ITGA5 ELISA Kit
MBS1606388-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3460

Human Integrin alpha-5, ITGA5 ELISA Kit
MBS1606388-48StripWells	MyBiosource	48-Strip-Wells	EUR 285

Human Integrin alpha-5, ITGA5 ELISA Kit
MBS1606388-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1750

Human Integrin alpha-5, ITGA5 ELISA Kit
MBS1606388-96StripWells	MyBiosource	96-Strip-Wells	EUR 425

Human Integrin Alpha 5 (ITGa5) CLIA Kit
20-abx492595	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Integrin alpha-5
AP84250	SAB	1mg	EUR 2640

Integrin alpha-5
AP84313	SAB	1mg	EUR 2640

Integrin alpha-5
AP84459	SAB	1mg	EUR 2640

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human)
4-PAB287Hu01	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5)

Human Integrin Alpha 5 (ITGa5) ELISA Kit
20-abx151987	Abbexa	Ask for price Ask for price Ask for price	10 × 96 tests 5 × 96 tests 96 tests

Human Integrin Alpha 5 (ITGA5) ELISA Kit
abx571172-96tests	Abbexa	96 tests	EUR 886.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit
DLR-ITGa5-Hu	DL Develop	96T	EUR 443
Description: tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
DLR-ITGa5-Hu-48T	DL Develop	48T	EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
DLR-ITGa5-Hu-96T	DL Develop	96T	EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKN46145-48T	Biomatik Corporation	48T	EUR 359.87

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKN46145-5x96T	Biomatik Corporation	5x96T	EUR 2441.98

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKN46145-96T	Biomatik Corporation	96T	EUR 514.1

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKU05034-48T	Biomatik Corporation	48T	EUR 527.66

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKU05034-5x96T	Biomatik Corporation	5x96T	EUR 3580.55

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EKU05034-96T	Biomatik Corporation	96T	EUR 753.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit
DL-ITGa5-Hu	DL Develop	96T	EUR 421
Description: tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
EK15036	SAB	96Т	EUR 768

Human Integrin alpha- 5, ITGA5 ELISA KIT
ELI-07691h	Nova Lifetech	96tests	EUR 696

Human Integrin Alpha 5(ITGa5) ELISA Kit
QY-E05294	Qayee Biotechnology	96T	EUR 472.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RDR-ITGa5-Hu-48T	Reddot Biotech	48T	EUR 453.92
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RDR-ITGa5-Hu-48Tests	Reddot Biotech	48 Tests	EUR 626.4

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RDR-ITGa5-Hu-96T	Reddot Biotech	96T	EUR 648.38
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RDR-ITGa5-Hu-96Tests	Reddot Biotech	96 Tests	EUR 868.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RD-ITGa5-Hu-48T	Reddot Biotech	48T	EUR 432.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RD-ITGa5-Hu-48Tests	Reddot Biotech	48 Tests	EUR 600

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RD-ITGa5-Hu-96T	Reddot Biotech	96T	EUR 617.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
RD-ITGa5-Hu-96Tests	Reddot Biotech	96 Tests	EUR 830.4

Human Integrin Alpha 5 (ITGa5) ELISA Kit
SEB287Hu-10x96wellstestplate	Cloud-Clone	10x96-wells test plate	EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
SEB287Hu-1x48wellstestplate	Cloud-Clone	1x48-wells test plate	EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
SEB287Hu-1x96wellstestplate	Cloud-Clone	1x96-wells test plate	EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
SEB287Hu-5x96wellstestplate	Cloud-Clone	5x96-wells test plate	EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
4-SEB287Hu	Cloud-Clone	Ask for price Ask for price Ask for price	10 plates of 96 wells 5 plates of 96 wells 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha 5 (ITGa5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2023182-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 5100

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2023182-24StripWells	MyBiosource	24-Strip-Wells	EUR 350

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2023182-48StripWells	MyBiosource	48-Strip-Wells	EUR 520

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2023182-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2795

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2023182-96StripWells	MyBiosource	96-Strip-Wells	EUR 695

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS4500517-10x96Tests	MyBiosource	10x96Tests	EUR 5060

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS4500517-48Tests	MyBiosource	48Tests	EUR 445

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS4500517-5x96Tests	MyBiosource	5x96Tests	EUR 2600

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS4500517-96Test	MyBiosource	96Test	EUR 585

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS455685-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 4890

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS455685-48StripWells	MyBiosource	48-Strip-Wells	EUR 425

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS455685-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 2495

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS455685-96StripWells	MyBiosource	96-Strip-Wells	EUR 560

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2703128-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 2980

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2703128-24StripWells	MyBiosource	24-Strip-Wells	EUR 245

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2703128-48StripWells	MyBiosource	48-Strip-Wells	EUR 325

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2703128-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1555

Human Integrin Alpha 5 (ITGa5) ELISA Kit
MBS2703128-96StripWells	MyBiosource	96-Strip-Wells	EUR 395

Human ITGA5/ Integrin alpha-5 ELISA Kit
E1342Hu	Sunlong	1 Kit	EUR 515
Description: FNRA,CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5,CD49e

Human ITGA5(Integrin alpha-5) ELISA Kit
EH2445	FN Test	96T	EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human ITGA5 / Integrin alpha-5 ELISA Kit
E9148h	EIAab	96T	EUR 736

Human Integrin Alpha-5, ITGA5 GENLISA ELISA
KBH5482	Krishgen	1 x 96 wells	EUR 286

Integrin alpha 5
E8ET1701-58	EnoGene	100ul	EUR 275
Description: Available in various conjugation types.

Integrin alpha 5
MBS8534265-01mL	MyBiosource	0.1mL	EUR 345

Integrin alpha 5
MBS8534265-01mLAF405L	MyBiosource	0.1mL(AF405L)	EUR 565

Integrin alpha 5
MBS8534265-01mLAF405S	MyBiosource	0.1mL(AF405S)	EUR 565

Integrin alpha 5
MBS8534265-01mLAF610	MyBiosource	0.1mL(AF610)	EUR 565

Integrin alpha 5
MBS8534265-01mLAF635	MyBiosource	0.1mL(AF635)	EUR 565

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS212234-02mg	MyBiosource	0.2mg	EUR 500

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS212234-5x02mg	MyBiosource	5x0.2mg	EUR 2070

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS215105-0025mg	MyBiosource	0.025mg	EUR 210

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS215105-5x0025mg	MyBiosource	5x0.025mg	EUR 765

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS213386-01mg	MyBiosource	0.1mg	EUR 920

MOUSE ANTI HUMAN INTEGRIN ALPHA 9 BETA 1
MBS213386-5x01mg	MyBiosource	5x0.1mg	EUR 3965

Integrin alpha-5 Antibody
abx234347-100ug	Abbexa	100 ug	EUR 610.8

Integrin alpha-5 Antibody
abx234347-100g	Abbexa	100 µg	EUR 350

Human ITGa5(Integrin Alpha 5) ELISA Kit
ELK3746-48T	ELK Biotech	48T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ITGa5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ITGa5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ITGa5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ITGa5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ITGa5(Integrin Alpha 5) ELISA Kit
ELK3746-96T	ELK Biotech	96T	Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ITGa5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ITGa5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ITGa5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ITGa5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ITGa5 (Integrin Alpha 5) ELISA Kit
MBS8802747-10x96StripWells	MyBiosource	10x96-Strip-Wells	EUR 3130

Human ITGa5 (Integrin Alpha 5) ELISA Kit
MBS8802747-48StripWells	MyBiosource	48-Strip-Wells	EUR 350

Human ITGa5 (Integrin Alpha 5) ELISA Kit
MBS8802747-5x96StripWells	MyBiosource	5x96-Strip-Wells	EUR 1710

Human ITGa5 (Integrin Alpha 5) ELISA Kit
MBS8802747-96StripWells	MyBiosource	96-Strip-Wells	EUR 445

Integrin alpha 5 Antibody
49269	SAB	100ul	EUR 529

Integrin alpha 5 Antibody
49269-100ul	SAB	100ul	EUR 399.6

Integrin alpha 5 Antibody
49269-50ul	SAB	50ul	EUR 286.8

Integrin alpha 5 Antibody
AF5200	Affbiotech	200ul	EUR 420

Integrin alpha 5 Antibody
AF5200-100ul	Affinity Biosciences	100ul	EUR 280

Integrin alpha 5 Antibody
AF5200-200ul	Affinity Biosciences	200ul	EUR 350

Integrin alpha 5 Antibody
F41992-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody
F49220-0.4ML	NSJ Bioreagents	0.4 ml	EUR 322.15
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody
R31667	NSJ Bioreagents	100 ug	EUR 356.15
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Integrin alpha 5 Antibody
MBS9436016-005mL	MyBiosource	0.05mL	EUR 315

Integrin alpha 5 Antibody
MBS9436016-01mL	MyBiosource	0.1mL	EUR 455

Integrin alpha 5 Antibody
MBS9436016-5x01mL	MyBiosource	5x0.1mL	EUR 1910

Human integrin alpha-5 beta-3, His-tag
REC31719-100	The Native Antigen Company	0.1	EUR 463.1
Description: Recombinant human integrin alpha-5 beta-3 protein produced in HEK293 with a C-terminal 6x histidine tag.

Human integrin alpha-5 beta-3, His-tag
REC31719-500	The Native Antigen Company	0.5	EUR 1622.75
Description: Recombinant human integrin alpha-5 beta-3 protein produced in HEK293 with a C-terminal 6x histidine tag.

Recombinant Human Integrin alpha-5 (ITGA5) , partial
MBS951298-005mgBaculovirus	MyBiosource	0.05mg(Baculovirus)	EUR 1000

Recombinant Human Integrin alpha-5 (ITGA5) , partial
MBS951298-005mgEColi	MyBiosource	0.05mg(E-Coli)	EUR 665

Recombinant Human Integrin alpha-5 (ITGA5) , partial
MBS951298-005mgYeast	MyBiosource	0.05mg(Yeast)	EUR 830

Recombinant Human Integrin alpha-5 (ITGA5) , partial
MBS951298-02mgEColi	MyBiosource	0.2mg(E-Coli)	EUR 860

Recombinant Human Integrin alpha-5 (ITGA5) , partial
MBS951298-05mgEColi	MyBiosource	0.5mg(E-Coli)	EUR 945

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), PE
4-PAB287Hu01-PE	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with PE.

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), APC
4-PAB287Hu01-APC	Cloud-Clone	Ask for price Ask for price Ask for price Ask for price Ask for price	100ul 10ml 1ml 200ul 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with APC.