antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and through transendocytosis into ligand cells

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labonet

NOTCH3-targeted antibody drug conjugates regress tumors by inducing apoptosis in receptor cells and thru transendocytosis into ligand cells

 

Aberrant NOTCH3 signaling and overexpression is oncogenic, related with most cancers stem cells and drug resistance, but therapeutic focusing on stays elusive. Right here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjugation of an auristatin microtubule inhibitor by way of a protease cleavable linker to 2 antibodies with differential talents to inhibit signaling. The signaling inhibitory antibody quickly induces ligand-independent receptor clustering and internalization by way of each caveolin and clathrin-mediated pathways.

The non-inhibitory antibody additionally effectively endocytoses through clathrin with out inducing receptor clustering however with slower lysosomal co-localization kinetics. As well as, DLL4 ligand binding to the NOTCH3 receptor mediates transendocytosis of NOTCH3-ADCs into ligand-expressing cells. NOTCH3-ADCs internalize into receptor and ligand cells impartial of signaling and induce cell loss of life in each cell sorts representing an atypical mechanism of ADC cytotoxicity. Therapy of xenografts with NOTCH3-ADCs results in sustained tumor regressions, outperforms standard-of-care chemotherapy, and permits focusing on of tumors that overexpress NOTCH3 impartial of signaling inhibition.

Fc-binding antibody-recruiting molecules exploit endogenous antibodies for anti-tumor immune responses

Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising method to set off anti-tumor immune responses. Nonetheless, present molecular designs solely allow the usage of a small fraction of endogenous antibodies, limiting the therapeutic potential. Right here, we report Fc-binding antibody-recruiting molecules (Fc-ARMs) as the primary instance addressing this challenge. Fc-ARMs are composed of an Fc-binding peptide and a focusing on ligand, enabling the exploitation of endogenous antibodies by way of fixed affinity to the Fc area of antibodies, whose sequence is conserved in distinction to the Fab area.

We present that Fc-ARM focusing on folate receptor-α (FR-α) redirects a clinically used antibody combination to FR-α+ most cancers cells, leading to most cancers cell lysis by pure killer cells in vitro. Fc-ARMs efficiently interacted with antibodies in vivo and collected in tumors. Moreover, Fc-ARMs recruited antibodies to suppress tumor development in a mouse mannequin. Thus, Fc-ARMs have the potential to be a novel class of most cancers immunotherapeutic brokers.

Mouse TGFR ELISA Kit

EMT0062 96Tests
EUR 625.2

Sheep TGFR ELISA Kit

EST0062 96Tests
EUR 625.2

Monkey TGFR ELISA Kit

EMKT0062 96Tests
EUR 625.2

Rabbit TGFR ELISA Kit

ERTT0062 96Tests
EUR 625.2

Canine TGFR ELISA Kit

ECT0062 96Tests
EUR 625.2

Bovine TGFR ELISA Kit

EBT0062 96Tests
EUR 625.2

Porcine TGFR ELISA Kit

EPT0062 96Tests
EUR 625.2

Chicken TGFR ELISA Kit

ECKT0062 96Tests
EUR 625.2

Anserini TGFR ELISA Kit

EAT0062 96Tests
EUR 625.2

Guinea Pig TGFR ELISA Kit

EGT0062 96Tests
EUR 625.2

Human ALK-1 Antibody Pair Set

ABPR-ZB169 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human ALK-1

Recombinant Human ALK-1 Protein

VAng-2860Lsx-10g 10 µg
EUR 736.8
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein

VAng-2860Lsx-1mg 1 mg
EUR 16605.6
Description: Recombinant Human ALK-1 was expressed in Sf9 Insect Cells. (Uniprot ID: P37023)

GOAT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML

9450431 1ML
EUR 207.65

RABBIT ANTI HUMAN IGG, INTACT IGG, ALK PHOS, 1 ML

9450511 1ML
EUR 228.15

Human ACVRL1 / ALK-1, Fc Tag

E24PHA006 50 μg
EUR 180

Human ACVRL1 / ALK-1, His Tag

E24PHA007 50 μg
EUR 225

Human ALK-1/ACVRL1 ELISA Kit

EK5715 96 tests
EUR 599

Goat anti Human IgG (Alk Phos)

43C-CB0963 1 mg
EUR 351
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43C-CB0978 1 mg
EUR 394
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgM (Alk Phos)

43C-CB0999 1 mg
EUR 347
Description: Goat anti Human IgM secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-1169 1 mg
EUR 167
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-1175 1 mg
EUR 208
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-1192 1 mg
EUR 250
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-1204 500 ug
EUR 293
Description: Goat anti Human IgG secondary antibody  (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-IG012alk 1 ml
EUR 522
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Goat anti Human IgG (Alk Phos)

43R-IG165ALK 1 mg
EUR 208
Description: Goat anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)

43C-CB0949 1 mg
EUR 44
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)

43C-CB0956 1 mg
EUR 387
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgG (Alk Phos)

43C-CB0970 1 mg
EUR 387
Description: Rabbit anti Human IgG secondary antibody (Alk Phos)

Rabbit anti Human IgM (Alk Phos)

43C-CB9106 1 mg
EUR 425
Description: Rabbit anti Human IgM secondary antibody (Alk Phos)

Rabbit anti Human IgA (Alk Phos)

43C-CB9120 1 mg
EUR 385
Description: Rabbit anti Human IgA secondary antibody (Alk Phos)

Nori® Human ALK-1 ELISA Kit

GR111542 96-well
EUR 461

Human ALK and LTK ligand 1 (ALKAL1)

1-CSB-EP757795HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human ALK and LTK ligand 1(ALKAL1) expressed in E.coli

Anti-ACVRL1 / ALK-1 Reference Antibody (ascrinvacumab)

E24CHA111 100 μg
EUR 225
Description: Available in various conjugation types.

Human ALK-1 / ACVRL1 Protein, His Tag

AL1-H5228 100ug
EUR 2140
Description: Human ALK-1, His Tag (AL1-H5228) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Gln 118 (Accession # P37023).

GOAT ANTI HUMAN IGA, U CHAIN, INTACT IGG, ALK PHOS, 1 ML

9450381 1ML
EUR 258.89

GOAT ANTI HUMAN IGG, FCY FRAG, INTACT IGG, ALK PHOS, 1 ML

9450581 1ML
EUR 258.89

GOAT ANTI HUMAN IGM, FC5U FRAG, INTACT IGG, ALK PHOS, 1 ML

9450641 1ML
EUR 269.14

ALK-1 Polyclonal Antibody

41591-100ul 100ul
EUR 302.4

ALK-1 Polyclonal Antibody

41591-50ul 50ul
EUR 224.4

ALK-1 Polyclonal Antibody

E041591 100μg/100μl
EUR 255
Description: Available in various conjugation types.

ALK-1 Polyclonal Antibody

E20-75182 100ug
EUR 225
Description: Available in various conjugation types.

ALK-1 Polyclonal Antibody

E20-70198 100ug
EUR 225
Description: Available in various conjugation types.

ALK-1 Polyclonal Antibody

ABP52913-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1

ALK-1 Polyclonal Antibody

ABP52913-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1

ALK-1 Polyclonal Antibody

ABP52913-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the N-terminal region of human ALK-1

ALK-1 Polyclonal Antibody

ABP57032-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250

ALK-1 Polyclonal Antibody

ABP57032-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250

ALK-1 Polyclonal Antibody

ABP57032-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of ALK-1 from Human, Mouse, Rat. This ALK-1 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human ALK-1 at AA range: 170-250

ALK-1 Polyclonal Antibody

E44H06624 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ALK-1 Polyclonal Antibody

E44H03961 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

ALK-1 Antibody, Concentrate

MAB663C 0.2ml
EUR 475

Human ALK-1/ACVRL1 PicoKine ELISA Kit

EK1518 96 wells
EUR 510
Description: For quantitative detection of human ALK-1 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

OKRC00141-96W - ALK-1 ELISA Kit (Human)

OKRC00141-96W 96Wells
EUR 550

Rabbit Anti-Human ALK-1 monoclonal antibody, clone S215

CABT-ZB592 50 μl
EUR 520
Description: Rabbit

Rabbit Anti-Human ALK-1 monoclonal antibody, clone S135

CABT-ZB944 50 μl
EUR 520
Description: Rabbit

Goat anti Human IgG Fc (Alk Phos)

43-I24 100 ug
EUR 125
Description: Goat anti Human IgG Fc secondary antibody (Alk Phos)

Recombinant Human ALK-1 Protein, His Tag

E40KMP1394 20ug
EUR 495

Anti-ALK-1 antibody

STJ96547 200 µl
EUR 236.4
Description: Rabbit polyclonal to ALK-1.

Anti-ALK-1 antibody

STJ91563 200 µl
EUR 236.4
Description: Rabbit polyclonal to ALK-1.

Active Recombinant Human ALK-1/ACVRL1 Protein

RP00978 5 μg
EUR 39

Goat anti Human Kappa Chain (Alk Phos)

43C-CB9127 1 mg
EUR 403
Description: Goat anti Human Kappa Chain secondary antibody (Alk Phos)

Goat anti Human kappa chain (Alk Phos)

43R-1257 500 ug
EUR 398
Description: Goat anti Human kappa chain secondary antibody (Alk Phos)

Goat anti Human Lambda Chain (Alk Phos)

43C-CB9134 1 mg
EUR 403
Description: Goat anti Human Lambda Chain secondary antibody (Alk Phos)

ALK-IN-1

T3059-10mg 10mg Ask for price
Description: ALK-IN-1

ALK-IN-1

T3059-1g 1g Ask for price
Description: ALK-IN-1

ALK-IN-1

T3059-1mg 1mg Ask for price
Description: ALK-IN-1

ALK-IN-1

T3059-50mg 50mg Ask for price
Description: ALK-IN-1

ALK-IN-1

T3059-5mg 5mg Ask for price
Description: ALK-IN-1

ALK-IN-1

HY-13464 100mg
EUR 472.8

ALK inhibitor 1

HY-15357 50mg
EUR 1712.4

ALK inhibitor 1

T10285-10mg 10mg Ask for price
Description: ALK inhibitor 1

ALK inhibitor 1

T10285-1g 1g Ask for price
Description: ALK inhibitor 1

ALK inhibitor 1

T10285-1mg 1mg Ask for price
Description: ALK inhibitor 1

ALK inhibitor 1

T10285-50mg 50mg Ask for price
Description: ALK inhibitor 1

ALK inhibitor 1

T10285-5mg 5mg Ask for price
Description: ALK inhibitor 1

Goat anti Human IgG (H + L) (Alk Phos)

43C-CB0921 1 mg
EUR 152
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)

43C-CB0928 1 mg
EUR 349
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)

43C-CB0935 1 mg
EUR 464
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)

43R-1145 1 mg
EUR 208
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)

43R-1157 500 ug
EUR 208
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG (H + L) (Alk Phos)

43R-1163 500 ug
EUR 250
Description: Goat anti Human IgG (H + L) secondary antibody (Alk Phos)

Sheep Polyclonal anti-human TGF beta RI (ALK-5)

hAP-5571 50ug
EUR 400

Recombinant Human ALK-1 Protein (aa 22-503)

VAng-2854Lsx-100g 100 µg
EUR 8440.8
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-503)

VAng-2854Lsx-50g 50 µg
EUR 5454
Description: Recombinant Human ALK-1 was expressed in cell free expression systems. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)

VAng-2856Lsx-1mg 1 mg
EUR 3393.6
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)

VAng-2856Lsx-200g 200 µg
EUR 2205.6
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 22-118)

VAng-2856Lsx-500g 500 µg
EUR 2419.2
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Human ALK And LTK Ligand 1 (ALKAL1) Protein

abx691053-100g 100 µg
EUR 962.5

Human ALK And LTK Ligand 1 (ALKAL1) Protein

abx691053-1mg 1 mg Ask for price

Rabbit anti Human IgG (H + L) (Alk Phos)

43-I23 1 mg
EUR 340
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Rabbit anti Human IgG (H + L) (Alk Phos)

43C-CB0914 1 mg
EUR 391
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgG + IgA + IgM (Alk Phos)

43R-1245 1 mg
EUR 152
Description: Goat anti Human IgG + IgA + IgM secondary antibody  (Alk Phos)

Goat anti Human IgG + IgA + IgM (Alk Phos)

43R-1251 500 ug
EUR 208
Description: Goat anti Human IgG + IgA + IgM secondary antibody  (Alk Phos)

Rabbit anti Human IgG (H + L) (Alk Phos)

43R-1269 1 mg
EUR 232
Description: Rabbit anti Human IgG (H + L) secondary antibody (Alk Phos)

Donkey anti Human IgG (H + L) (Alk Phos)

43R-ID001alk 500 ul
EUR 315
Description: Donkey anti Human IgG (H + L) secondary antibody (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)

43-I34 1 mg
EUR 176
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)

43R-1227 1 mg
EUR 211
Description: Goat anti Human IgM (mu chain) secondary antibody (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)

43R-1233 500 ug
EUR 375
Description: Goat anti Human IgM (mu chain) secondary antibody  (Alk Phos)

Goat anti Human IgM (mu chain) (Alk Phos)

43R-1239 500 ug
EUR 375
Description: Goat anti Human IgM (mu chain) secondary antibody  (Alk Phos)

ALK sgRNA CRISPR Lentivector (Human) (Target 1)

K0074502 1.0 ug DNA
EUR 184.8

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

CSB-EP757795HU 4101 mg Ask for price

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

CSB-BP757795HU 228 mg Ask for price

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

RPC28141-100ug 100ug
EUR 1544.5

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

RPC28141-20ug 20ug
EUR 580.8

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

RPC23238-100ug 100ug
EUR 705.1

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

RPC23238-1mg 1mg
EUR 3237

Recombinant Human ALK and LTK ligand 1 (ALKAL1)

RPC23238-20ug 20ug
EUR 353.4

Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)

PKSH033782-10ug 10ug
EUR 37
Description: Human

Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)

PKSH033782-50ug 50ug
EUR 111
Description: Human

Recombinant Human ALK-1/ACVRL1 Protein, His Tag

E40KMH659 20ug
EUR 495

Goat anti Human IgA (alpha chain) (Alk Phos)

43-I10 1 mg
EUR 285
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos)

Goat anti Human IgA (alpha chain) (Alk Phos)

43R-1119 500 ug
EUR 293
Description: Goat anti Human IgA (alpha chain) secondary antibody (Alk Phos)

Goat anti Human IgG (gamma chain) (Alk Phos)

43R-1659 1 mg
EUR 301.2
Description: Goat anti Human IgG (gamma chain) secondary antibody (Alkaline Phosphatase)

ALK-1 Rabbit Polyclonal Antibody

ES3912-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

ALK-1 Rabbit Polyclonal Antibody

ES3912-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

ALK-1 Rabbit Polyclonal Antibody

ES8031-100ul 100ul
EUR 124
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

ALK-1 Rabbit Polyclonal Antibody

ES8031-50ul 50ul
EUR 74
Description: A Rabbit Polyclonal antibody against ALK-1 from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Goat anti Human IgE (epsilon chain) (Alk Phos)

43R-1129 1 mg
EUR 375
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos)

Goat anti Human IgE (epsilon chain) (Alk Phos)

43R-1134 500 ug
EUR 375
Description: Goat anti Human IgE (epsilon chain) secondary antibody (Alk Phos)

Recombinant Human ALK-5/TGFBR1 (C-Fc)

PKSH033907-10ug 10ug
EUR 210
Description: Human

Recombinant Human ALK-5/TGFBR1 (C-Fc)

PKSH033907-50ug 50ug
EUR 630
Description: Human

ALK-1 Polyclonal Conjugated Antibody

C41591 100ul
EUR 476.4

ALK-1 Rabbit pAb

E2251845 100ul
EUR 225
Description: Available in various conjugation types.

ALK-1 Rabbit mAb

E2R381919 100ul
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Anti-ALK Antibody Clone ALK/1503, Unconjugated-20ug

238-MSM3-P0 20ug
EUR 279.6

Anti-ALK Antibody Clone ALK/1503, Unconjugated-100ug

238-MSM3-P1 100ug
EUR 513.6

Goat Anti Human Ige Polyclonal Antibody,Alk. Phos.

CPBT-65486GH 0.5 mg
EUR 696

ALK-1 Recombinant Protein

92-565 0.05 mg
EUR 374.1
Description: Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF- beta superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1 is mainly expressed in endothelial cells regulating proliferation and migration in vitro and angiogenesis in vivo. Mutations in ALK-1 as well as in endoglin are associated with hereditary hemorrhagic telangiectasia (HHT), suggesting ALK-1 plays a critical role for in the control of blood vessel development or repair.

Human ALK Tyrosine Kinase Receptor (ALK) Protein

abx168161-1ml 1 ml
EUR 225

Human ALK And LTK Ligand 1 (ALKAL1) ELISA Kit

abx522764-96tests 96 tests
EUR 687.5

Human ALKAL1 / ALK and LTK ligand 1 ELISA Kit

E15393h 96T
EUR 736

Recombinant Human ALK-1 Protein (aa 22-118) [Fc]

VAng-2859Lsx-50g 50 µg
EUR 621.6
Description: Recombinant Human ALK-1 was expressed in HEK 293 cells. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 238-479) [His]

VAng-2861Lsx-1mg 1 mg
EUR 3952.8
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 238-479) [His]

VAng-2861Lsx-200g 200 µg
EUR 1429.2
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human ALK-1 Protein (aa 238-479) [His]

VAng-2861Lsx-500g 500 µg
EUR 2700
Description: Recombinant Human ALK-1 was expressed in E. coli. (Uniprot ID: P37023)

Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc)

C422-10ug 10ug
EUR 96
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc)

C422-1mg 1mg
EUR 1216.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc)

C422-500ug 500ug
EUR 790.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Activin Receptor-Like Kinase 1/ALK-1(C-Fc)

C422-50ug 50ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)(Active)

PKSH031899-100ug 100ug
EUR 670
Description: Human

Recombinant Human ALK-1/ACVRL1 Protein (Fc Tag)(Active)

PKSH031899-1mg 1mg
EUR 4372
Description: Human

ALK/ROS1-IN-1

T10286-10mg 10mg Ask for price
Description: ALK/ROS1-IN-1

ALK/ROS1-IN-1

T10286-1g 1g Ask for price
Description: ALK/ROS1-IN-1

ALK/ROS1-IN-1

T10286-1mg 1mg Ask for price
Description: ALK/ROS1-IN-1

ALK/ROS1-IN-1

T10286-50mg 50mg Ask for price
Description: ALK/ROS1-IN-1

ALK/ROS1-IN-1

T10286-5mg 5mg Ask for price
Description: ALK/ROS1-IN-1

Recombinant Human TGFBR1/ALK-5 protein (His tag)

PDEH100272-100ug 100ug
EUR 118
Description: Human

Recombinant Human TGFBR1/ALK-5 protein (His tag)

PDEH100272-20ug 20ug
EUR 68
Description: Human

Recombinant Human ALK-1/ACVRL1 Protein (His Tag)(Active)

PKSH031898-100ug 100ug
EUR 670
Description: Human

Recombinant Human ALK-1/ACVRL1 Protein (His Tag)(Active)

PKSH031898-1mg 1mg
EUR 4372
Description: Human

Goat Anti Human Igg (Fc) Polyclonal Antibody,Alk. Phos.

CPBT-65492GH 1 mg
EUR 920.4

anti- ALK,CD246 antibody

FNab00309 100µg
EUR 606.3
Description: Antibody raised against ALK,CD246

anti- ALK,CD246 antibody

FNab00310 100µg
EUR 606.3
Description: Antibody raised against ALK,CD246

Human ALK/ ALK tyrosine kinase receptor ELISA Kit

E0122Hu 1 Kit
EUR 515
Description: Anaplastic lymphoma kinase,CD246

Human ALK tyrosine kinase receptor, ALK ELISA KIT

ELI-03653h 96 Tests
EUR 988.8

Human ALK/ALK tyrosine kinase receptor ELISA Kit

EK19470 96Т
EUR 553

Significance of hepatitis B floor antigen, IgM/IgG core antibody and hepatitis B virus DNA in blood donors

Introduction: Identification of hepatitis B virus carriers in blood donors is crucial as a way to keep away from transmission of the illness through blood transfusion.

Goal: To find out if blood donors with optimistic outcomes for serological markers HBsAg and anti-HBc have been hepatitis B virus DNA carriers.

Strategies: 12,745 samples have been collected from six Ecuadorian blood banks and analyzed for HBsAg, anti-HBc and anti-HBs infectious markers by automated ELISA. All samples that examined optimistic for one, two or all three markers have been analyzed with molecular strategies to find out the presence of viral DNA.

Outcomes: 27.5 % of the samples that have been reactive for anti-HBc alone and 100 % of these with optimistic outcomes for HbsAg and IgM/IgG anti-HBc have been recognized to include hepatitis B virus DNA (p = 0.001).

Conclusions: The collection of an infection markers, in addition to the detection strategies outline the outcomes. Performing two serological and one molecular take a look at is necessary as a way to establish hepatitis B virus carriers and forestall its transmission.

Introducción: La identificación de portadores del virus de la hepatitis B en donantes de sangre es imperativo para evitar la transmisión de la enfermedad a través de transfusiones sanguíneas.

Objetivo: Determinar si los donantes de sangre con resultados positivos en los marcadores serológicos HbsAg y anti-HBc eran portadores del ADN del virus de la hepatitis B.

Métodos: Se recolectaron 12 745 muestras de seis bancos de sangre ecuatorianos, las cuales fueron analizadas con pruebas serológicas para identificar marcadores infecciosos de HBsAg, anti-HBc, anti-HBs mediante ELISA automatizada. Todas las muestras positivas para uno, dos o los tres marcadores fueron analizadas con técnica molecular para determinar la presencia del ADN viral.

Resultados: Se identificó que 27.5 % de las muestras reactivas solo a anti-HBc y 100 % de las muestras con resultados positivos de HBsAg/anti-HBc-IgM/IgG presentaron ADN del virus de la hepatitis B (p = 0.001).

Conclusiones: La elección de los marcadores de infección y los métodos de detección definen los resultados. Es importante la realización de dos pruebas serológicas y una molecular para identificar a los portadores del virus de la hepatitis B y evitar su transmisión.

Two human antibodies to a meningococcal serogroup B vaccine antigen improve binding of complement Issue H by stabilizing the Issue H binding website

Microbial pathogens bind host complement regulatory proteins to evade the immune system. The bacterial pathogen Neisseria meningitidis, or meningococcus, binds a number of complement regulators, together with human Issue H (FH). FH binding protein (FHbp) is a element of two licensed meningococcal vaccines and in mice FHbp elicits antibodies that inhibit binding of FH to FHbp, which defeat the bacterial evasion mechanism. Nonetheless, people vaccinated with FHbp develop antibodies that improve binding of FH to the micro organism, which might restrict the effectiveness of the vaccines. Within the current examine, we present that two vaccine-elicited antibody fragments (Fabs) remoted from totally different human topics enhance binding of complement FH to meningococcal FHbp by ELISA.

The 2 Fabs have totally different results on the kinetics of FH binding to immobilized FHbp as measured by floor plasmon resonance. The 1.7- and a pair of.0-Å decision X-ray crystal constructions of the Fabs in complexes with FHbp illustrate that the 2 Fabs bind to related epitopes on the amino-terminal area of FHbp, adjoining to the FH binding website. Superposition fashions of ternary complexes of every Fab with FHbp and FH present that there’s possible minimal contact between the Fabs and FH. Collectively, the constructions reveal that the Fabs improve binding of FH to FHbp by altering the conformations and mobilities of two loops adjoining to the FH binding website of FHbp. As well as, the 1.5 Å-resolution construction of one of many remoted Fabs defines the structural rearrangements related to binding to FHbp. The FH-enhancing human Fabs, that are mirrored within the human polyclonal antibody responses, have necessary implications for tuning the effectiveness of FHbp-based vaccines.

 

Human Integrin Alpha 5 ELISA Kit

IHUITGA5KT each
EUR 700
Description: Human Integrin Alpha 5 ELISA Kit

Integrin alpha 5

E8ET1701-58 100ul
EUR 275
Description: Available in various conjugation types.

Integrin alpha-5 Antibody

abx234347-100ug 100 ug
EUR 610.8

Integrin alpha-5 Antibody

abx234347-100g 100 µg
EUR 350

Human Integrin Alpha 5 (ITGa5) Protein

20-abx067272
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Integrin Alpha 5 (ITGa5) Protein

abx067272-100g 100 µg
EUR 550

Human Integrin Alpha 5 (ITGa5) Protein

abx067272-10g 10 µg
EUR 212.5

Human Integrin Alpha 5 (ITGa5) Protein

abx067272-50g 50 µg
EUR 387.5

Integrin alpha 5 Antibody

49269 100ul
EUR 529

Integrin alpha 5 Antibody

49269-100ul 100ul
EUR 399.6

Integrin alpha 5 Antibody

49269-50ul 50ul
EUR 286.8

Integrin alpha 5 Antibody

AF5200 200ul
EUR 420

Integrin alpha 5 Antibody

AF5200-100ul 100ul
EUR 280

Integrin alpha 5 Antibody

AF5200-200ul 200ul
EUR 350

Integrin alpha 5 Antibody

F41992-0.4ML 0.4 ml
EUR 322.15
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody

F49220-0.4ML 0.4 ml
EUR 322.15
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody

R31667 100 ug
EUR 356.15
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Human Integrin alpha-5(ITGA5) Elisa Kit

EK712764 96 Wells
EUR 0.29

Human Integrin alpha-5(ITGA5) Elisa kit

CSB-E17350h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5 (ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Integrin alpha-5(ITGA5) Elisa kit

1-CSB-E17350h
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  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Integrin alpha-5(ITGA5) in samples from serum, plasma, cell culture supernates, urine, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Integrin alpha-5 (ITGA5) ELISA Kit

RK11332 96T
EUR 280

Human Integrin alpha-5(ITGA5) Elisa kit

YLA4349HU-48T 48T Ask for price

Human Integrin alpha-5(ITGA5) Elisa kit

YLA4349HU-96T 96T Ask for price

Mouse Anti Human Integrin Alpha V Beta 5 Monoclonal Antibody

CABT-49626MH 0.1 mg
EUR 1650

Human Integrin Alpha 5 (ITGa5) CLIA Kit

20-abx492595
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human ITGA5/ Integrin alpha-5 ELISA Kit

E1342Hu 1 Kit
EUR 515
Description: FNRA,CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5,CD49e

Human ITGA5(Integrin alpha-5) ELISA Kit

EH2445 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml

Human ITGA5 / Integrin alpha-5 ELISA Kit

E9148h 96T
EUR 736

Human Integrin Alpha 5 (ITGa5) ELISA Kit

20-abx151987
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Integrin Alpha 5 (ITGA5) ELISA Kit

abx571172-96tests 96 tests
EUR 886.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit

DLR-ITGa5-Hu 96T
EUR 443
Description: tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

DLR-ITGa5-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

DLR-ITGa5-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Integrin Alpha 5 (ITGa5) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKN46145-48T 48T
EUR 359.87

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKN46145-5x96T 5x96T
EUR 2441.98

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKN46145-96T 96T
EUR 514.1

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKU05034-48T 48T
EUR 527.66

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKU05034-5x96T 5x96T
EUR 3580.55

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EKU05034-96T 96T
EUR 753.8

Human Integrin alpha- 5, ITGA5 ELISA KIT

ELI-07691h 96 Tests
EUR 988.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit

DL-ITGa5-Hu 96T
EUR 421
Description: tissue homogenates, cell lysates or other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

EK15036 96Т
EUR 768

Human Integrin Alpha 5(ITGa5) ELISA Kit

QY-E05294 96T
EUR 472.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RDR-ITGa5-Hu-48T 48T
EUR 453.92
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RDR-ITGa5-Hu-48Tests 48 Tests
EUR 626.4

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RDR-ITGa5-Hu-96T 96T
EUR 648.38
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RDR-ITGa5-Hu-96Tests 96 Tests
EUR 868.8

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RD-ITGa5-Hu-48T 48T
EUR 432.3
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RD-ITGa5-Hu-48Tests 48 Tests
EUR 600

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RD-ITGa5-Hu-96T 96T
EUR 617.5
Description: tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

RD-ITGa5-Hu-96Tests 96 Tests
EUR 830.4

Human Integrin Alpha 5 (ITGa5) ELISA Kit

SEB287Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

SEB287Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

SEB287Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

SEB287Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Integrin Alpha 5 (ITGa5) in Tissue homogenates, cell lysates and other biological fluids.

Human Integrin Alpha 5 (ITGa5) ELISA Kit

4-SEB287Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Integrin Alpha 5 (ITGa5) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Integrin Alpha-5, ITGA5 GENLISA ELISA

KBH5482 1 x 96 wells
EUR 286

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human)

4-PAB287Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5)

Human ITGa5(Integrin Alpha 5) ELISA Kit

ELK3746-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ITGa5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ITGa5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ITGa5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ITGa5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ITGa5(Integrin Alpha 5) ELISA Kit

ELK3746-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ITGa5. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ITGa5. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ITGa5, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ITGa5 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human integrin alpha-5 beta-3, His-tag

REC31719-100 0.1
EUR 463.1
Description: Recombinant human integrin alpha-5 beta-3 protein produced in HEK293 with a C-terminal 6x histidine tag.

Human integrin alpha-5 beta-3, His-tag

REC31719-500 0.5
EUR 1622.75
Description: Recombinant human integrin alpha-5 beta-3 protein produced in HEK293 with a C-terminal 6x histidine tag.

Integrin Alpha 5 (ITGA5) Antibody

20-abx113185
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  • 150 ul
  • 50 ul

Integrin Alpha 5 (ITGa5) Antibody

20-abx101634
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha 5 (ITGa5) Antibody

20-abx101635
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  • 100 ug
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  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha 5 (ITGa5) Antibody

20-abx129339
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Integrin Alpha 5 (ITGA5) Antibody

20-abx006811
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  • 100 ul
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Integrin Alpha 5 (ITGA5) Antibody

abx026655-400ul 400 ul
EUR 627.6

Integrin Alpha 5 (ITGA5) Antibody

abx026655-80l 80 µl
EUR 343.2

Integrin Alpha 5 (ITGA5) Antibody

abx011678-100ul 100 ul
EUR 493.2

Integrin Alpha 5 (ITGA5) Antibody

20-abx000873
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  • 100 ul
  • 200 ul

Integrin Alpha 5 (ITGa5) Antibody

20-abx172956
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  • 1 mg
  • 200 ug

Integrin alpha 5 (CD49e) Antibody

abx216264-100ug 100 ug
EUR 526.8

Integrin Alpha 5 (ITGa5) Antibody

20-abx179024
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  • 1 mg
  • 200 ug

Integrin Alpha 5 (ITGA5) Antibody

20-abx338742
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Integrin Alpha 5 (ITGA5) Antibody

20-abx325454
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  • 100 ug
  • 50 ug

Integrin Alpha 5 (ITGA5) Antibody

20-abx327245
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  • 100 ug
  • 50 ug

Integrin Alpha 5 (ITGA5) Antibody

20-abx323564
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  • 100 ug
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Integrin alpha 5 Antibody (ITGA5)

F41992-0.08ML 0.08 ml
EUR 140.25
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody (ITGA5)

F49220-0.08ML 0.08 ml
EUR 140.25
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [provided by RefSeq].

Integrin alpha 5 Antibody / ITGA5

RQ5245 100ul
EUR 356.15
Description: The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [RefSeq]

Integrin alpha 5 Antibody / ITGA5

RQ4096 100 ug
EUR 356.15
Description: Integrin alpha-5, also known as FNRA or VLA5A, is a protein that in humans is encoded by the ITGA5 gene. The product of this gene belongs to the integrin alpha chain family. Integrins are integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the integrin alpha 5 chain. Alpha chain 5 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form a fibronectin receptor. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

Integrin Alpha 5 (ITGA5) Antibody

abx011678-100g 100 µg Ask for price

Integrin Alpha 5 (ITGA5) Antibody

abx011678-10g 10 µg
EUR 362.5

Integrin Alpha 5 (ITGA5) Antibody

abx011678-200g 200 µg Ask for price

Integrin Alpha 5 (ITGA5) Antibody

abx006811-100g 100 µg
EUR 275

Integrin Alpha 5 (ITGA5) Antibody

abx006811-10g 10 µg
EUR 175

Integrin Alpha 5 (ITGA5) Antibody

abx006811-200g 200 µg
EUR 400

Integrin Alpha 5 (ITGa5) Antibody

abx101634-100l 100 µl
EUR 262.5

Integrin Alpha 5 (ITGa5) Antibody

abx101634-1ml 1 ml
EUR 712.5

Integrin Alpha 5 (ITGa5) Antibody

abx101634-200l 200 µl
EUR 325

Integrin Alpha 5 (ITGa5) Antibody

abx101635-100l 100 µl
EUR 287.5

Integrin Alpha 5 (ITGa5) Antibody

abx101635-1ml 1 ml
EUR 850

Integrin Alpha 5 (ITGa5) Antibody

abx101635-200l 200 µl
EUR 375

Integrin Alpha 5 (ITGA5) Antibody

abx113185-100l 100 µl
EUR 612.5

Integrin Alpha 5 (ITGa5) Antibody

abx129339-100l 100 µl
EUR 262.5

Integrin Alpha 5 (ITGa5) Antibody

abx129339-1ml 1 ml
EUR 725

Integrin Alpha 5 (ITGa5) Antibody

abx129339-200l 200 µl
EUR 337.5

Integrin Alpha 5 (ITGa5) Antibody

abx172956-100l 100 µl
EUR 750

Integrin Alpha 5 (ITGa5) Antibody

abx172956-1ml 1 ml Ask for price

Integrin Alpha 5 (ITGa5) Antibody

abx172956-200l 200 µl Ask for price

Integrin Alpha 5 (ITGA5) Antibody

abx026655-400l 400 µl
EUR 518.75

Integrin Alpha 5 (ITGA5) Antibody

abx140572-100g 100 µg
EUR 212.5

Integrin Alpha 5 (ITGA5) Antibody

abx140598-100g 100 µg
EUR 212.5

Integrin Alpha 5 (ITGa5) Antibody

abx179024-96tests 96 tests
EUR 1225

Integrin Alpha 5 (ITGA5) Antibody

abx338742-100l 100 µl
EUR 250

Integrin Alpha 5 (ITGA5) Antibody

abx338742-50l 50 µl
EUR 162.5

Integrin Alpha 5 (ITGA5) Antibody

abx327245-100g 100 µg
EUR 250

Integrin Alpha 5 (ITGA5) Antibody

abx327245-50g 50 µg
EUR 187.5

Human Integrin alpha-M

E01A5419 96T
EUR 700
Description: ELISA

Human Integrin alpha-X

E01A5432 96T
EUR 700
Description: ELISA

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), PE

4-PAB287Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with PE.

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), APC

4-PAB287Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with APC.

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), Cy3

4-PAB287Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with Cy3.

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), HRP

4-PAB287Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with HRP.

Recombinant Antibody to Integrin Alpha 5 (ITGa5) (Human)

4-RAB287Hu21
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Recombinant antibody against Human Integrin Alpha 5 (ITGa5)

Integrin Alpha 5 (ITGa5) Polyclonal Antibody (Human), FITC

4-PAB287Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Integrin Alpha 5 (ITGa5). This antibody is labeled with FITC.

ELISA kit for Human ITGa5 (Integrin Alpha 5)

ELK3746 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Integrin Alpha 5 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

FITC anti-mouse/rat CD49e (Integrin alpha 5)

E16FMF049e-200U 200 μg
EUR 823.33
Description: Available in various conjugation types.

Integrin alpha 5 Conjugated Antibody

C49269 100ul
EUR 476.4

Integrin Alpha-5 (ITGA5) Antibody (PE)

abx140909-100g 100 µg
EUR 262.5

Integrin alpha 5 Mouse mAb

E2222376 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

anti- Integrin alpha-1 antibody

FNab04343 100µg
EUR 702
Description: Antibody raised against Integrin alpha-1

anti- Integrin alpha-3 antibody

FNab04344 100µg
EUR 702
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-3 antibody

FNab04345 100µg
EUR 702
Description: Antibody raised against Integrin alpha-3

anti- Integrin alpha-4 antibody

FNab04346 100µg
EUR 606.3
Description: Antibody raised against Integrin alpha-4

anti- Integrin alpha-9 antibody

FNab04348 100µg
EUR 606.3
Description: Antibody raised against Integrin alpha-9

Integrin alpha 5 Rabbit mAb

59189 100ul
EUR 339

Integrin alpha 5 Rabbit pAb

E2381532 100ul
EUR 225
Description: Available in various conjugation types.

Integrin alpha 5 Rabbit mAb

E2R24725 100ul
EUR 255
Description: Available in various conjugation types.

Integrin alpha 5 Rabbit mAb

A19069-100ul 100 ul
EUR 492

Integrin alpha 5 Rabbit mAb

A19069-200ul 200 ul
EUR 685.2

Integrin alpha 5 Rabbit mAb

A19069-20ul 20 ul
EUR 265.2

Integrin alpha 5 Rabbit mAb

A19069-50ul 50 ul
EUR 344.4

Integrin Alpha-5 (ITGA5) Antibody (FITC)

abx140906-100g 100 µg
EUR 237.5

Human Integrin alpha-2 (ITGA2)

1-CSB-YP011864HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Integrin alpha-2(ITGA2),partial expressed in Yeast

Human Integrin alpha-2 (ITGA2)

1-CSB-EP011864HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Integrin alpha-2(ITGA2) ,partial expressed in E.coli

Anti-Human Integrin alpha 2 Antibody

101-M515 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 3 Antibody

101-M516 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 4 Antibody

101-M517 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha 6 Antibody

101-M519 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha M Antibody

101-M520 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

Anti-Human Integrin alpha V Antibody

101-M521 100 µg
EUR 399
Description: Integrins are transmembrane proteins that mediate interactions between adhesion molecules on adjacent cells and/or the extracellular matrix (ECM). Integrins have diverse roles in several biological processes including cell migration during development and wound healing, cell differentiation, and apoptosis. Their activities can also regulate the metastatic and invasive potential of tumor cells. They exist as heterodimers consisting of alpha and beta subunits. Some alpha and beta subunits exhibit specificity for one another and may be designated as a VLA (very late antigen) member. Heterodimers often preferentially bind certain cell adhesion molecules, or constituents of the ECM. Although they have no catalytic activity, integrins can be part of multimolecular signaling complexes known as focal adhesions.

 

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